• Androgens are differentially associated with ovarian cancer subtypes in the Ovarian Cancer Cohort Consortium 

      Ose, Jennifer; Poole, Elizabeth M.; Schock, Helena; Lehtinen, Matti; Arslan, Alan A.; Zeleniuch-Jacquotte, Anne; Visvanathan, Kala; Helzlsouer, Kathy; Buring, Julie E.; Lee, I-Min; Tjønneland, Anne; Dossus, Laure; Trichopoulou, Antonia; Masala, Giovanna; Onland-Moret, N. Charlotte; Weiderpass, Elisabete; Duell, Eric J.; Idahl, Annika; Travis, Ruth C.; Rinaldi, Sabina; Merritt, Melissa A.; Trabert, Britton; Wentzensen, Nicolas; Tworoger, Shelley S.; Kaaks, Rudolf; Fortner, Renée T. (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-04-05)
      Invasive epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy. The etiology of EOC remains elusive; however, experimental and epidemiologic data suggest a role for hormone-related exposures in ovarian carcinogenesis and risk factor differences by histologic phenotypes and developmental pathways. Research on pre-diagnosis androgen concentrations and EOC risk has yielded inconclusive ...
    • Daily steps and all-cause mortality: a meta-analysis of 15 international cohorts 

      Paluch, Amanda E; Bajpai, Shivangi; Bassett, David R; Carnethon, Mercedes R; Ekelund, Ulf; Evenson, Kelly R; Galuska, Deborah A; Jefferis, Barbara J; Kraus, William E; Lee, I-Min; Matthews, Charles E; Omura, John D; Patel, Alpa V; Pieper, Carl F; Rees-Punia, Erika; Dallmeier, Dhayana; Klenk, Jochen; Whincup, Peter H; Dooley, Erin E; Pettee Gabriel, Kelley; Palta, Priya; Pompeii, Lisa A; Chernofsky, Ariel; Larson, Martin G; Vasan, Ramachandran S; Spartano, Nicole; Ballin, Marcel; Nordström, Peter; Nordström, Anna Hava; Anderssen, Sigmund Alfred; Hansen, Bjørge Hermann; Cochrane, Jennifer A; Dwyer, Terence; Wang, Jing; Ferrucci, Luigi; Liu, Fangyu; Schrack, Jennifer; Urbanek, Jacek; Saint-Maurice, Pedro F; Yamamoto, Naofumi; Yoshitake, Yutaka; Newton, Robert L; Yang, Shengping; Shiroma, Eric J; Fulton, Janet E (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-22)
      Background Although 10000 steps per day is widely promoted to have health benefits, there is little evidence to support this recommendation. We aimed to determine the association between number of steps per day and stepping rate with all-cause mortality.<p> <p>Methods In this meta-analysis, we identified studies investigating the effect of daily step count on all-cause mortality in adults (aged ...
    • Genome-wide association study identifies multiple risk loci for renal cell carcinoma 

      Scelo, Ghislaine; Purdue, Mark P.; Brown, Kevin M.; Johansson, Mattias; Wang, Zhaoming; Eckel-Passow, Jeanette E.; Ye, Yuanqing; Hofmann, Jonathan N.; Choi, Jiyeon; Foll, Matthieu; Gaborieau, Valerie; Machiela, Mitchell J.; Colli, Leandro M.; Li, Peng; Sampson, Joshua N.; Abedi-Ardekani, Behnoush; Besse, Celine; Blanche, Helene; Boland, Anne; Burdette, Laurie; Chabrier, Amelie; Durand, Geoffroy; Le Calvez-Kelm, Florence; Prokhortchouk, Egor; Robinot, Nivonirina; Skryabin, Konstantin G.; Wozniak, Magdalena B.; Yeager, Meredith; Basta-Jovanovic, Gordana; Dzamic, Zoran; Foretova, Lenka; Holcatova, Ivana; Janout, Vladimir; Mates, Dana; Mukeriya, Anush; Rascu, Stefan; Zaridze, David; Bencko, Vladimir; Cybulski, Cezary; Fabianova, Eleonora; Jinga, Viorel; Lissowska, Jolanta; Lubinski, Jan; Navratilova, Marie; Rudnai, Peter; Szeszenia-Dabrowska, Neonila; Benhamou, Simone; Cancel-Tassin, Geraldine; Cussenot, Olivier; Baglietto, Laura; Boeing, Heiner; Khaw, Kay-Tee; Weiderpass, Elisabete; Ljungberg, Börje; Sitaram, Raviprakash T.; Bruinsma, Fiona; Jordan, Susan J.; Severi, Gianluca; Winship, Ingrid; Hveem, Kristian; Vatten, Lars Johan; Fletcher, Tony; Koppova, Kvetoslava; Larsson, Susanna C.; Wolk, Alicja; Banks, Rosamonde E.; Selby, Peter J.; Easton, Douglas F.; Pharoah, Paul; Andreotti, Gabriella; Freeman, Laura E Beane; Koutros, Stella; Albanes, Demetrius; Männistö, Satu; Weinstein, Stephanie; Clark, Peter E.; Edwards, Todd L.; Lipworth, Loren; Gapstur, Susan M.; Stevens, Victoria L.; Carol, Hallie; Freedman, Matthew L.; Pomerantz, Mark M.; Cho, Eunyoung; Kraft, Peter; Preston, Mark A.; Wilson, Kathryn M.; Gaziano, J. Michael; Sesso, Howard D.; Black, Amanda; Freedman, Neal D.; Huang, Wen-Yi; Anema, John G.; Kahnoski, Richard J.; Lane, Brian R.; Noyes, Sabrina L.; Petillo, David; Teh, Bin Tean; Peters, Ulrike; White, Emily; Anderson, Garnet L.; Johnson, Lisa; Luo, Juhua; Buring, Julie; Lee, I-Min; Chow, Wong-Ho; Moore, Lee E.; Wood, Christopher; Eisen, Timothy; Henrion, Marc; Larkin, James; Barman, Poulami; Leibovich, Bradley C.; Choueiri, Toni K.; Lathrop, G. Mark; Rothman, Nathaniel; Deleuze, Jean-Francois; McKay, James D.; Parker, Alexander S.; Wu, Xifeng; Houlston, Richard S.; Brennan, Paul; Chanock, Stephen J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-06-09)
      Previous genome-wide association studies (GWAS) have identified six risk loci for renal cell carcinoma (RCC). We conducted a meta-analysis of two new scans of 5,198 cases and 7,331 controls together with four existing scans, totalling 10,784 cases and 20,406 controls of European ancestry. Twenty-four loci were tested in an additional 3,182 cases and 6,301 controls. We confirm the six known RCC risk ...
    • The influence of obesity-related factors in the etiology of renal cell carcinoma-A mendelian randomization study 

      Johansson, Mattias; Carreras-Torres, Robert; Scelo, Ghislaine; Purdue, Mark P.; Mariosa, Daniela; Muller, David C.; Timpson, Nicholas J.; Haycock, Philip C.; Brown, Kevin M.; Wang, Zhaoming; Ye, Yuanqing; Hofmann, Jonathan N.; Foll, Matthieu; Gaborieau, Valerie; Machiela, Mitchell J.; Colli, Leandro M.; Li, Peng; Garnier, Jean-Guillaume; Blanche, Helene; Boland, Anne; Burdette, Laurie; Prokhortchouk, Egor; Skryabin, Konstantin G.; Yeager, Meredith; Radojevic-Skodric, Sanja; Ognjanovic, Simona; Foretova, Lenka; Holcatova, Ivana; Janout, Vladimir; Mates, Dana; Mukeriya, Anush; Rascu, Stefan; Zaridze, David; Bencko, Vladimir; Cybulski, Cezary; Fabianova, Eleonora; Jinga, Viorel; Lissowska, Jolanta; Lubinski, Jan; Navratilova, Marie; Rudnai, Peter; Benhamou, Simone; Cancel-Tassin, Geraldine; Cussenot, Olivier; Weiderpass, Elisabete; Ljungberg, Börje; Tumkur Sitaram, Raviprakash; Häggström, Christel; Bruinsma, Fiona; Jordan, Susan J.; Severi, Gianluca; Winship, Ingrid; Hveem, Kristian; Vatten, Lars Johan; Fletcher, Tony; Larsson, Susanna C.; Wolk, Alicja; Banks, Rosamonde E.; Selby, Peter J.; Easton, Douglas F.; Andreotti, Gabriella; Beane Freeman, Laura E.; Koutros, Stella; Männistö, Satu; Weinstein, Stephanie; Clark, Peter E.; Edwards, Todd L.; Lipworth, Loren; Gapstur, Susan M.; Stevens, Victoria L.; Carol, Hallie; Freedman, Matthew L.; Pomerantz, Mark M.; Cho, Eunyoung; Wilson, Kathryn M.; Gaziano, J. Michael; Sesso, Howard D.; Freedman, Neal D.; Parker, Alexander S.; Eckel-Passow, Jeanette E.; Huang, Wen-Yi; Kahnoski, Richard J.; Lane, Brian R.; Noyes, Sabrina L.; Petillo, David; Teh, Bin Tean; Peters, Ulrike; White, Emily; Anderson, Garnet L.; Johnson, Lisa; Luo, Juhua; Buring, Julie; Lee, I-Min; Chow, Wong-Ho; Moore, Lee E.; Eisen, Timothy; Henrion, Marc; Larkin, James; Barman, Poulami; Leibovich, Bradley C.; Choueiri, Toni K.; Lathrop, G. Mark; Deleuze, Jean-François; Gunter, Marc; McKay, James D.; Wu, Xifeng; Houlston, Richard S.; Chanock, Stephen J.; Relton, Caroline; Richards, J. Brent; Martin, Richard M.; Davey Smith, George; Brennan, Paul (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-03)
      <i>Background</i> - Several obesity-related factors have been associated with renal cell carcinoma (RCC), but it is unclear which individual factors directly influence risk. We addressed this question using genetic markers as proxies for putative risk factors and evaluated their relation to RCC risk in a mendelian randomization (MR) framework. This methodology limits bias due to confounding and is ...
    • Leisure Time Physical Activity of Moderate to Vigorous Intensity and Mortality: A Large Pooled Cohort Analysis 

      Moore, Steven C.; Patel, Alpa; Matthews, Charles E.; de Gonzalez, Amy Berrington; Park, Yikyung; Katki, Hormuzd A.; Linet, Martha S.; Weiderpass, Elisabete; Visvanathan, Kala; Helzlsouer, Kathy J; Thun, Michael; Gapstur, Susan M; Hartge, Patricia; Lee, I-Min (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Leisure time physical activity reduces the risk of premature mortality, but the years of life expectancy gained at different levels remains unclear. Our objective was to determine the years of life gained after age 40 associated with various levels of physical activity, both overall and according to body mass index (BMI) groups, in a large pooled analysis. We examined the association of leisure ...
    • Ovarian cancer risk factors by tumor aggressiveness: An analysis from the Ovarian Cancer Cohort Consortium 

      Fortner, Renée T.; Poole, Elizabeth M.; Wentzensen, Nicolas A.; Trabert, Britton; White, Emily; Arslan, Alan A.; Patel, Alpa V.; Setiawan, V. Wendy; Visvanathan, Kala; Weiderpass, Elisabete; Adami, Hans Olov; Black, Amanda; Bernstein, Leslie; Brinton, Louise A.; Buring, Julie; Clendenen, Tess V.; Fournier, Agnès; Fraser, Gary; Gapstur, Susan M.; Gaudet, Mia M.; Giles, Graham G.; Gram, Inger Torhild; Hartge, Patricia; Hoffman-Bolton, Judith; Idahl, Annika; Kaaks, Rudolf; Kirsh, Victoria A.; Knutsen, Synnøve; Koh, Woon-Puay; Lacey, James V.; Lee, I-Min; Lundin, Eva; Merritt, Melissa A.; Milne, Roger L.; Onland-Moret, N. Charlotte; Peters, Ulrike; Poynter, Jenny N.; Rinaldi, Sabina; Robien, Kim; Rohan, Thomas; Sánchez, María-José; Schairer, Catherine; Schouten, Leo J.; Tjønneland, Anne; Townsend, Mary K.; Travis, Ruth C.; Trichopoulou, Antonia; van den Brandt, Piet A.; Vineis, Paolo; Wilkens, Lynne; Wolk, Alicja; Yang, Hannah P.; Zeleniuch-Jacquotte, Anne; Tworoger, Shelley S. (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-18)
    • Pre-diagnosis insulin-like growth factor-I and risk of epithelial invasive ovarian cancer by histological subtypes: A collaborative re-analysis from the Ovarian Cancer Cohort Consortium 

      Ose, Jennifer; Schock, Helena; Poole, Elizabeth M.; Lehtinen, Matti; Visvanathan, Kala; Helzlsouer, Kathy; Buring, Julie E.; Lee, I-Min; Tjønneland, Anne; Boutron-Ruault, Marie-Christine; Trichopoulou, Antonia; Mattiello, Amalia; Onland-Moret, N. Charlotte; Weiderpass, Elisabete; Sánchez, María-José; Idahl, Annika; Travis, Ruth C.; Rinaldi, Sabina; Merritt, Melissa A.; Wentzensen, Nicolas; Tworoger, Shelley S.; Kaaks, Rudolf; Fortner, Renée T. (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-16)
      Purpose: <br>Biologic evidence suggests that the Insulin-like growth factor (IGF)-family may be involved in the etiology of epithelial invasive ovarian cancer (EOC). However, prospective studies investigating the role of IGF-I in ovarian carcinogenesis have yielded conflicting results.<br> Methods: <br>We pooled and harmonized data from 6 case-control studies nested within the Ovarian Cancer ...
    • Prospective Association of Daily Steps with Cardiovascular Disease: A Harmonized Meta-Analysis 

      Paluch, Amanda E.; Bajpai, Shivangi; Ballin, Marcel; Bassett, David R.; Buford, Thomas W.; Carnethon, Mercedes R.; Chernofsky, Ariel; Dooley, Erin E.; Ekelund, Ulf; Evenson, Kelly R.; Galuska, Deborah A.; Jefferis, Barbara J.; Kong, Lingsong; Kraus, William E.; Larson, Martin G.; Lee, I-Min; Matthews, Charles E.; Newton, Robert L.; Nordström, Anna Hava; Nordström, Peter; Palta, Priya; Patel, Alpa V.; Pettee Gabriel, Kelley; Pieper, Carl F.; Pompeii, Lisa; Rees-Punia, Erika; Spartano, Nicole L.; Vasan, Ramachandran S.; Whincup, Peter H.; Yang, Shengping; Fulton, Janet E. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-20)
      Background: Taking fewer than the widely promoted “10 000 steps per day” has recently been associated with lower risk of all-cause mortality. The relationship of steps and cardiovascular disease (CVD) risk remains poorly described. A meta-analysis examining the dose–response relationship between steps per day and CVD can help inform clinical and public health guidelines. Methods: Eight prospective ...